Analysis Note

single spot by TLC

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

k₂ = 28,900 M_-¹s_-¹ in the inhibition of calpain II; k2 = 680,000 M_-¹s_-¹ in the inhibition of cathepsin L

Cell permeable: yes

Primary Targetcalpain 2

General description

A potent, cell-permeable, and irreversible inhibitor of calpain II (k₂ = 28,900 M^-1s^-1). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M^-1s^-1).

A potent, cell-permeable and irreversible inhibitor of calpain II (k₂ = 28,900 M^-1s^-1). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M^-1s^-1).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Dutt, P., et al. 1998. FEBS Lett. 436, 367.Angliker, H., et al. 1992. J. Med. Chem. 35, 216.

Packaging

1 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sequence

Z-Leu-Leu-Tyr-CH₂F

Warning

Toxicity: Standard Handling (A)